Beilstein J. Org. Chem.2017,13, 2710–2738, doi:10.3762/bjoc.13.269
in their structures.
Keywords: 2-aminovinylphosphoniumsalts; nucleophilic addition; phosphorus ylides; vinylphosphonium salts; Wittig reaction; Introduction
Vinylphosphonium salts have been known for a long time, although significant interest in these compounds dates back to 1964, when Schweizer
. Schweizer's discovery became the basis for the wide use of vinylphosphonium salts in organic synthesis while stimulating the development of methods for the synthesis of those compounds.
Wide synthetic application, particularly for the synthesis of heterocycles found also 2-aminovinylphosphoniumsalts and
their derivatives. The preparation and synthetic use of these compounds were presented by Drach, Brovarets and Smolii in a comprehensive review in 2002 [4]. In this paper we will discuss only the last reports on the synthesis and properties of 2-aminovinylphosphoniumsalts and their derivatives that
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Graphical Abstract
Scheme 1:
Generation of phosphorus ylides from vinylphosphonium salts.